Unveiling Colitis: A Journey through the Dextran Sodium Sulfate-induced Model

Animal models of inflammatory bowel disease (IBD) are valuable tools for investigating the factors involved in IBD pathogenesis and evaluating new therapeutic options. The dextran sodium sulfate (DSS)-induced model of colitis is arguably the most widely used animal model for studying the pathogenesis of and potential treatments for ulcerative colitis (UC), which is a primary form of IBD. This model offers several advantages as a research tool: it is highly reproducible, relatively easy to generate and maintain, and mimics many critical features of human IBD. Recently, it has also been used to study the role of gut microbiota in the development and progression of IBD and to investigate the effects of other…

• UD
  U.S. Department of Veterans Affairs

  Awards: RO1-DK-116306, BX002526, BX004476
• NI
  National Institute of Diabetes and Digestive and Kidney Diseases

  Award: RO1-DK-116306