In-situ-sprayed therapeutic hydrogel for oxygen-actuated Janus regulation of postsurgical tumor recurrence/metastasis and wound healing

Abstract Surgery is the mainstay of treatment modality for malignant melanoma. However, the deteriorative hypoxic microenvironment after surgery is recognized as a stemming cause for tumor recurrence/metastasis and delayed wound healing. Here we design and construct a sprayable therapeutic hydrogel (HIL@Z/P/H) encapsulating tumor-targeted nanodrug and photosynthetic cyanobacteria (PCC 7942) to prevent tumor recurrence/metastasis while promote wound healing. In a postsurgical B16F10 melanoma model in female mice, the nanodrug can disrupt cellular redox homeostasis via the photodynamic therapy-induced cascade reactions within tumor cells. Besides, the photosynthetically generated O 2 by PCC 7942 can not only…

• NN
  National Natural Science Foundation of China

  Awards: 52033007, 51903214, 51903214, 52033007
• SJ
  Southwest Jiaotong University
• DO
  Department of Science and Technology of Sichuan Province

  Award: 2022ZYD0069
• FR
  Fundamental Research Funds for the Central Universities

  Award: 2682023ZTPY074