Using Cu‐Based Metal–Organic Framework as a Comprehensive and Powerful Antioxidant Nanozyme for Efficient Osteoarthritis Treatment

Developing nanozymes with effective reactive oxygen species (ROS) scavenging ability is a promising approach for osteoarthritis (OA) treatment. Nonetheless, numerous nanozymes lie in their relatively low antioxidant activity. In certain circumstances, some of these nanozymes may even instigate ROS production to cause side effects. To address these challenges, a copper-based metal-organic framework (Cu MOF) nanozyme is designed and applied for OA treatment. Cu MOF exhibits comprehensive and powerful activities (i.e., SOD-like, CAT-like, and •OH scavenging activities) while negligible pro-oxidant activities (POD- and OXD-like activities). Collectively, Cu MOF nanozyme is more effective at scavenging various…

• NN
  National Natural Science Foundation of China

  Awards: B16029, 82372117, 12274356, 22275081
• SM
  Southern Medical University
• HE
  Higher Education Discipline Innovation Project

  Award: B16029
• NK
  National Key Research and Development Program of China

  Awards: 2022YFC3601900, 2022YFC3601902, 2021YFC2400602, 2022YFC3601900/2022YFC3601902, 2021YFC2400600/2021YFC2400602, 2021YFC2400600
• BA
  Basic and Applied Basic Research Foundation of Guangdong Province

  Award: 2022A1515011292