Chemically Modified Platforms for Better RNA Therapeutics
Brigham and Women's Hospital · Harvard University · +3 more institutions
Abstract
RNA-based therapies have catalyzed a revolutionary transformation in the biomedical landscape, offering unprecedented potential in disease prevention and treatment. However, despite their remarkable achievements, these therapies encounter substantial challenges including low stability, susceptibility to degradation by nucleases, and a prominent negative charge, thereby hindering further development. Chemically modified platforms have emerged as a strategic innovation, focusing on precise alterations either on the RNA moieties or their associated delivery vectors. This comprehensive review delves into these platforms, underscoring their significance in augmenting the performance and translational prospects of…
Citation impact
- FWCI
- 29.97
- Percentile
- 100%
- References
- 586
Authors
10- YSYesi Shi
Brigham and Women's Hospital, Harvard University, Xiamen University
- XZXueyan Zhen
Brigham and Women's Hospital, Harvard University
- YZYiming Zhang
Brigham and Women's Hospital, Harvard University
- YLYongjiang Li
Brigham and Women's Hospital, Harvard University
- SKSeyoung Koo
Brigham and Women's Hospital, Harvard University
Topics & keywords
- RNA
- Chemistry
- Transformative learning
- Bench to bedside
- Nanotechnology
- Computational biology
- Medicine
- Biology
- Industry, innovation and infrastructure