Indole-containing pharmaceuticals: targets, pharmacological activities, and SAR studies

Indole is a prestigious heterocyclic skeleton widely found in both naturally-occurring and biologically-active compounds. Pharmaceutical agents containing an indole skeleton in their framework possess a wide range of pharmacological properties, including antiviral, antitumor, analgesic, and other therapeutic activities, and many indole-containing drugs have been proven to have excellent pharmacokinetic and pharmacological effects. Over the past few decades, the FDA has approved over 40 indole-containing drugs for the treatment of various clinical conditions, and the development of indole-related drugs has attracted significant attention from medicinal chemists. This review aims to provide an overview of all…

• NN
  National Natural Science Foundation of China

  Awards: 22071175, 2019YFA0905100
• NK
  National Key Research and Development Program of China

  Award: 2019YFA0905100
• TR
  Tianjin Research Innovation Project for Postgraduate Students

  Award: 2021YJSB196