Metabolic reprogramming in the tumor microenvironment of liver cancer
Jinshan Hospital of Fudan University · First Affiliated Hospital Zhejiang University · +3 more institutions
Abstract
The liver is essential for metabolic homeostasis. The onset of liver cancer is often accompanied by dysregulated liver function, leading to metabolic rearrangements. Overwhelming evidence has illustrated that dysregulated cellular metabolism can, in turn, promote anabolic growth and tumor propagation in a hostile microenvironment. In addition to supporting continuous tumor growth and survival, disrupted metabolic process also creates obstacles for the anticancer immune response and restrains durable clinical remission following immunotherapy. In this review, we elucidate the metabolic communication between liver cancer cells and their surrounding immune cells and discuss how metabolic reprogramming of liver…
Citation impact
- FWCI
- 50.69
- Percentile
- 100%
- References
- 240
Authors
4- JLJian LinCorresponding
Jinshan Hospital of Fudan University, First Affiliated Hospital Zhejiang University, Zhejiang University
- DRDongning Rao
Fudan University, Zhongshan Hospital
- MZMao Zhang
Fudan University, Zhongshan Hospital
- QGQiang Gao
Fudan University, Jinshan Hospital of Fudan University, Zhongshan Hospital
Topics & keywords
- Tumor microenvironment
- Immune system
- Liver cancer
- Cancer research
- Crosstalk
- Immunotherapy
- Cancer
- Cancer immunotherapy
- Good health and well-being