Hydrogel dressings with intrinsic antibiofilm and antioxidative dual functionalities accelerate infected diabetic wound healing

Pranantyo, Dicky; Yeo, Chun Kiat; Wu, Yang; Fan, Chen; Xu, Xiaofei; Yip, Yun Sheng; Vos, Marcus Ivan Gerard; Mahadevegowda, Surendra H.; Lim, Priscilla Lay Keng; Yang, Liang; Hammond, Paula T.; Leavesley, David I.; Tan, Nguan Soon; Chan‐Park, Mary B.

doi:10.1038/s41467-024-44968-y

articleNature CommunicationsJan 31, 2024GOLD OA

Hydrogel dressings with intrinsic antibiofilm and antioxidative dual functionalities accelerate infected diabetic wound healing

DPDicky Pranantyo CKChun Kiat Yeo YWYang Wu CFChen Fan XXXiaofei Xu

Nanyang Technological University · Singapore-MIT Alliance for Research and Technology · +4 more institutions

PubMed

Indexed incrossrefdoajpubmed

Abstract

Chronic wounds are often infected with biofilm bacteria and characterized by high oxidative stress. Current dressings that promote chronic wound healing either require additional processes such as photothermal irradiation or leave behind gross amounts of undesirable residues. We report a dual-functionality hydrogel dressing with intrinsic antibiofilm and antioxidative properties that are synergistic and low-leaching. The hydrogel is a crosslinked network with tethered antibacterial cationic polyimidazolium and antioxidative N-acetylcysteine. In a murine diabetic wound model, the hydrogel accelerates the closure of wounds infected with methicillin-resistant Staphylococcus aureus or carbapenem-resistant…

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294

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FWCI: 66.47
Percentile: 100%
References: 60

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Topics & keywords

Topics

Keywords

Wound healing
Biofilm
Staphylococcus aureus
Chronic wound
Photothermal therapy
Pseudomonas aeruginosa
Ex vivo
In vivo

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