Gut microbiota-derived indole compounds attenuate metabolic dysfunction-associated steatotic liver disease by improving fat metabolism and inflammation

ABSTRACTMetabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease, and its prevalence has increased worldwide in recent years. Additionally, there is a close relationship between MASLD and gut microbiota-derived metabolites. However, the mechanisms of MASLD and its metabolites are still unclear. We demonstrated decreased indole-3-propionic acid (IPA) and indole-3-acetic acid (IAA) in the feces of patients with hepatic steatosis compared to healthy controls. Here, IPA and IAA administration ameliorated hepatic steatosis and inflammation in an animal model of WD-induced MASLD by suppressing the NF-κB signaling pathway through a reduction in endotoxin levels and…

• NR
  National Research Foundation
• HU
  Hallym University
• KI
  Korea Institute for Advancement of Technology

  Award: P0020622
• NR
  National Research Foundation of Korea

  Awards: NRF-2020R1A6A1A03043026, 2020R1A6A1A03043026
• MO
  Ministry of Education, Science and Technology

  Awards: NRF-2020R1A6A1A03043026, 2020R1A6A1A03043026