Achieving Clearance of Drug‐Resistant Bacterial Infection and Rapid Cutaneous Wound Regeneration Using an ROS‐Balancing‐Engineered Heterojunction
Sichuan University · West China Hospital of Sichuan University · +5 more institutions
Abstract
Abstract Intractable infected microenvironments caused by drug‐resistant bacteria stalls the normal course of wound healing. Sono‐piezodynamic therapy (SPT) is harnessed to combat pathogenic bacteria, but the superabundant reactive oxygen species (ROS) generated during SPT inevitably provoke severe inflammatory response, hindering tissue regeneration. Consequently, an intelligent nanocatalytic membrane composed of poly(lactic‐co‐glycolic acid) (PLGA) and black phosphorus /V 2 C MXene bio‐heterojunctions (2D 2 ‐bioHJs) is devised. Under ultrasonication, 2D 2 ‐bioHJs effectively eliminate drug‐resistant bacteria by disrupting metabolism and electron transport chain (ETC). When ultrasonication ceases, they enable…
Citation impact
- FWCI
- 31.25
- Percentile
- 100%
- References
- 69
Authors
11- CGChong Geng
Sichuan University, West China Hospital of Sichuan University
- SHShuai He
Sichuan University, West China Hospital of Sichuan University
- SYSheng Yu
Washington State University
- HMHannah M. Johnson
Washington State University
- HSHongxing Shi
Sichuan University, West China Hospital of Sichuan University
Topics & keywords
- Reactive oxygen species
- Bacteria
- Sonication
- Regeneration (biology)
- Materials science
- Drug
- Microbiology
- Wound healing