Single-Site Nanozymes with a Highly Conjugated Coordination Structure for Antitumor Immunotherapy via Cuproptosis and Cascade-Enhanced T Lymphocyte Activity
Nanyang Technological University · Chinese Academy of Sciences · +2 more institutions
Abstract
The extracellular matrix (ECM) in the tumor microenvironment (TME) and upregulated immune checkpoints (ICs) on antitumor immune cells impede the infiltration and killing effect of T cells, creating an immunosuppressive TME. Herein, a cholesterol oxidase (CHO) and lysyl oxidase inhibitor (LOX-IN-3) co-delivery copper-dibenzo-[g,p]chrysene-2,3,6,7,10,11,14,15-octaol single-site nanozyme (Cu-DBCO/CL) was developed. The conjugated organic ligand and well-distributed Cu-O4 sites endow Cu-DBCO with unique redox capabilities, enabling it to catalyze O2 and H2O2 to ·O2– and ·OH. This surge of reactive oxygen species (ROS) leads to impaired mitochondrial function and insufficient ATP supply, impacting the function of…
Citation impact
- FWCI
- 20.42
- Percentile
- 100%
- References
- 53
Authors
7- YLYang Liu
Nanyang Technological University
- RNRui Niu
Chinese Academy of Sciences, Changchun Institute of Applied Chemistry
- HZHuan Zhao
Nanyang Technological University
- YWYinghui WangCorresponding
Chinese Academy of Sciences, Changchun Institute of Applied Chemistry
- SSShuyan Song
Chinese Academy of Sciences, Changchun Institute of Applied Chemistry
Topics & keywords
- Chemistry
- Immune system
- Tumor microenvironment
- Cytotoxic T cell
- Cell biology
- Cancer research
- Biochemistry
- Immunology
- Life below water