Programmed microalgae-gel promotes chronic wound healing in diabetes
Tianjin University · Tianjin Medical University · +4 more institutions
Abstract
Abstract Chronic diabetic wounds are at lifelong risk of developing diabetic foot ulcers owing to severe hypoxia, excessive reactive oxygen species (ROS), a complex inflammatory microenvironment, and the potential for bacterial infection. Here we develop a programmed treatment strategy employing live Haematococcus (HEA). By modulating light intensity, HEA can be programmed to perform a variety of functions, such as antibacterial activity, oxygen supply, ROS scavenging, and immune regulation, suggesting its potential for use in programmed therapy. Under high light intensity (658 nm, 0.5 W/cm 2 ), green HEA (GHEA) with efficient photothermal conversion mediate wound surface disinfection. By decreasing the light…
Citation impact
- FWCI
- 58.41
- Percentile
- 100%
- References
- 75
Authors
9Topics & keywords
- Reactive oxygen species
- NADPH oxidase
- Wound healing
- Photothermal therapy
- PEDF
- Chemistry
- Cell biology
- Intracellular