Targeting ageing with rapamycin and its derivatives in humans: a systematic review
National University of Singapore · National University Health System · +1 more institution
Abstract
Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies. Rapamycin and its derivatives improved physiological parameters associated with ageing in the immune, cardiovascular, and integumentary systems of healthy individuals or individuals with ageing-related diseases. Overall, no significant effects on the endocrine, muscular, or neurological systems were found. The effects of rapamycin or its derivatives on the…
Citation impact
- FWCI
- 27.11
- Percentile
- 100%
- References
- 76
Authors
3Topics & keywords
- Ageing
- Computational biology
- Neuroscience
- Biology
- Medicine
- Internal medicine
- Zero hunger