An atlas of protein homo-oligomerization across domains of life

Schweke, Hugo; Pačesa, Martin; Levin, Tal; Goverde, Casper A.; Kumar, Prasun; Duhoo, Yoan; Dornfeld, L; Dubreuil, Benjamin; Georgeon, Sandrine; Ovchinnikov, Sergey; Woolfson, Derek N.; Correia, Bruno E.; Dey, Sucharita; Levy, Emmanuel D.

doi:10.1016/j.cell.2024.01.022

articleCellFeb 1, 2024HYBRID OA

An atlas of protein homo-oligomerization across domains of life

HSHugo Schweke MPMartin Pačesa TLTal Levin CACasper A. Goverde PKPrasun Kumar

Weizmann Institute of Science · SIB Swiss Institute of Bioinformatics · +5 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Protein structures are essential to understanding cellular processes in molecular detail. While advances in artificial intelligence revealed the tertiary structure of proteins at scale, their quaternary structure remains mostly unknown. We devise a scalable strategy based on AlphaFold2 to predict homo-oligomeric assemblies across four proteomes spanning the tree of life. Our results suggest that approximately 45% of an archaeal proteome and a bacterial proteome and 20% of two eukaryotic proteomes form homomers. Our predictions accurately capture protein homo-oligomerization, recapitulate megadalton complexes, and unveil hundreds of homo-oligomer types, including three confirmed experimentally by structure…

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Topics & keywords

Topics

Keywords

Biology
Atlas (anatomy)
Evolutionary biology
Computational biology
Genetics
Anatomy

UN Sustainable Development Goals

Zero hunger

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