articleFrontiers in ImmunologyFeb 6, 2024GOLD OA

Mechanisms underlying immunosuppression by regulatory cells

OGOliver GoldmannOVObiageli Vivian NwoforQCQian ChenEMEva Medina

Helmholtz Centre for Infection Research

PubMed
Indexed incrossrefdoajpubmed

Abstract

Regulatory cells, such as regulatory T cells (Tregs), regulatory B cells (Bregs), and myeloid-derived suppressor cells (MDSCs), play a crucial role in preserving immune tolerance and controlling immune responses during infections to prevent excessive immune activation. However, pathogens have developed strategies to hijack these regulatory cells to decrease the overall effectiveness of the immune response and persist within the host. Consequently, therapeutic targeting of these immunosuppressive mechanisms during infection can reinvigorate the immune response and improve the infection outcome. The suppressive mechanisms of regulatory cells are not only numerous but also redundant, reflecting the complexity of…

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4

Topics & keywords

Topics
Keywords
  • Immune system
  • Biology
  • Regulatory B cells
  • Regulatory T cell
  • Immunology
  • Context (archaeology)
  • Effector
  • Cell biology
UN Sustainable Development Goals
  • Good health and well-being
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