Programmed Targeting Pyruvate Metabolism Therapy Amplified Single‐Atom Nanozyme‐Activated Pyroptosis for Immunotherapy
University of Science and Technology of China · Chinese Academy of Sciences · +4 more institutions
Abstract
Abstract Increasing cellular immunogenicity and reshaping the immune tumor microenvironment (TME) are crucial for antitumor immunotherapy. Herein, this work develops a novel single‐atom nanozyme pyroptosis initiator: UK5099 and pyruvate oxidase (POx)‐co‐loaded Cu‐NS single‐atom nanozyme (Cu‐NS@UK@POx), that not only trigger pyroptosis through cascade biocatalysis to boost the immunogenicity of tumor cells, but also remodel the immunosuppressive TME by targeting pyruvate metabolism. By replacing N with weakly electronegative S, the original spatial symmetry of the Cu‐N 4 electron distribution is changed and the enzyme‐catalyzed process is effectively regulated. Compared to spatially symmetric Cu‐N 4 single‐atom…
Citation impact
- FWCI
- 17.87
- Percentile
- 100%
- References
- 48
Authors
14- RNRui Niu
University of Science and Technology of China, Chinese Academy of Sciences, Changchun Institute of Applied Chemistry
- YLYang LiuCorresponding
Chinese Academy of Sciences, Changchun Institute of Applied Chemistry
- BXBo Xu
Jilin University, First Hospital of Jilin University
- RDRuiping Deng
Chinese Academy of Sciences, Changchun Institute of Applied Chemistry
- SZShijie Zhou
University of Science and Technology of China
Topics & keywords
- Pyroptosis
- Oxidase test
- Biochemistry
- Tumor microenvironment
- Chemistry
- Immune system
- Immunotherapy
- Cancer research