articleNatureFeb 7, 2024HYBRID OA

Circulating myeloid-derived MMP8 in stress susceptibility and depression

FCFlurin CathomasHLHsiao‐Yun LinKLKenny L. ChanLLLong LiLFLyonna F. Parise

Allen Institute for Brain Science · Icahn School of Medicine at Mount Sinai · +4 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

, the underlying mechanisms are not well understood. Here we show that expression of a circulating myeloid cell-specific proteinase, matrix metalloproteinase 8 (MMP8), is increased in the serum of humans with MDD as well as in stress-susceptible mice following chronic social defeat stress (CSDS). In mice, we show that this increase leads to alterations in extracellular space and neurophysiological changes in the nucleus accumbens (NAc), as well as altered social behaviour. Using a combination of mass cytometry and single-cell RNA sequencing, we performed high-dimensional phenotyping of immune cells in circulation and in the brain and demonstrate that peripheral monocytes are strongly affected by stress. In…

Citation impact

149
total citations
FWCI
21.27
Percentile
100%
References
88
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Authors

30

Topics & keywords

Topics
Keywords
  • Immune system
  • Social defeat
  • Social stress
  • Immunology
  • Chronic stress
  • Major depressive disorder
  • Context (archaeology)
  • Medicine
UN Sustainable Development Goals
  • Reduced inequalities
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