Cancer cell plasticity: from cellular, molecular, and genetic mechanisms to tumor heterogeneity and drug resistance
Sher-i-Kashmir Institute of Medical Sciences · University of Jammu · +12 more institutions
Abstract
Cancer is a complex disease displaying a variety of cell states and phenotypes. This diversity, known as cancer cell plasticity, confers cancer cells the ability to change in response to their environment, leading to increased tumor diversity and drug resistance. This review explores the intricate landscape of cancer cell plasticity, offering a deep dive into the cellular, molecular, and genetic mechanisms that underlie this phenomenon. Cancer cell plasticity is intertwined with processes such as epithelial-mesenchymal transition and the acquisition of stem cell-like features. These processes are pivotal in the development and progression of tumors, contributing to the multifaceted nature of cancer and the…
Citation impact
- FWCI
- 56.15
- Percentile
- 100%
- References
- 258
Authors
17Topics & keywords
- Cancer
- Epigenetics
- Cancer cell
- Cancer stem cell
- Biology
- Phenotypic plasticity
- Epithelial–mesenchymal transition
- Cancer research