An Antioxidative and Active Shrinkage Hydrogel Integratedly Promotes Re‐Epithelization and Skin Constriction for Enhancing Wound Closure
Chinese Academy of Sciences · Beijing National Laboratory for Molecular Sciences · +2 more institutions
Abstract
Abstract Delayed re‐epithelization and weakened skin contractions are the two primary factors that hinder wound closure in large‐scale acute or chronic wounds. However, effective strategies for targeting these two aspects concurrently are still lacking. Herein, an antioxidative active‐shrinkage hydrogel (AHF@AS Gel) is constructed that can integratedly promote re‐epithelization and skin constriction to accelerate large‐scale acute and diabetic chronic wound closure. The AHF@AS Gel is encapsulated by antioxidative amino‐ and hydroxyl‐modified C 70 fullerene (AHF) and a thermosensitive active shrinkage hydrogel (AS Gel). Specifically, AHF relieves overactivated inflammation, prevents cellular apoptosis, and…
Citation impact
- FWCI
- 31.16
- Percentile
- 100%
- References
- 48
Authors
13- JSJiacheng Sun
Chinese Academy of Sciences, Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, University of Chinese Academy of Sciences
- WJWang Jia
Chinese Academy of Sciences, Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, University of Chinese Academy of Sciences
- HQHedong Qi
Chinese Academy of Sciences, Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, University of Chinese Academy of Sciences
- JHJiawei Huo
Chinese Academy of Sciences, Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, University of Chinese Academy of Sciences
- XLXiaodan Liao
Chinese Academy of Sciences, Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, University of Chinese Academy of Sciences
Topics & keywords
- Wound healing
- Self-healing hydrogels
- Materials science
- Protein kinase B
- Inflammation
- Chronic wound
- Fibroblast
- Apoptosis