Wnt/β-catenin-driven EMT regulation in human cancers
First Affiliated Hospital of Zhengzhou University · Xian Yang Central Hospital · +5 more institutions
Abstract
Metastasis accounts for 90% of cancer-related deaths among the patients. The transformation of epithelial cells into mesenchymal cells with molecular alterations can occur during epithelial-mesenchymal transition (EMT). The EMT mechanism accelerates the cancer metastasis and drug resistance ability in human cancers. Among the different regulators of EMT, Wnt/β-catenin axis has been emerged as a versatile modulator. Wnt is in active form in physiological condition due to the function of GSK-3β that destructs β-catenin, while ligand-receptor interaction impairs GSK-3β function to increase β-catenin stability and promote its nuclear transfer. Regarding the oncogenic function of Wnt/β-catenin, its upregulation…
Citation impact
- FWCI
- 57.48
- Percentile
- 100%
- References
- 242
Authors
6- WXWenhua Xue
First Affiliated Hospital of Zhengzhou University
- LYLin Yang
Xian Yang Central Hospital
- CCChengxin Chen
First Affiliated Hospital of Zhengzhou University
- MAMilad AshrafizadehCorresponding
Sun Yat-sen University, Fudan University, Zhongshan Hospital, The First Affiliated Hospital, Sun Yat-sen University
- YTYu TianCorresponding
Benedictine University
Topics & keywords
- Wnt signaling pathway
- Frizzled
- Metastasis
- Cancer research
- Epithelial–mesenchymal transition
- Catenin
- LRP6
- Beta-catenin
- Good health and well-being