Design and Application of Fluorescent Probes to Detect Cellular Physical Microenvironments
Westlake University · Dalian Institute of Chemical Physics · +2 more institutions
Abstract
The microenvironment is indispensable for functionality of various biomacromolecules, subcellular compartments, living cells, and organisms. In particular, physical properties within the biological microenvironment could exert profound effects on both the cellular physiology and pathology, with parameters including the polarity, viscosity, pH, and other relevant factors. There is a significant demand to directly visualize and quantitatively measure the fluctuation in the cellular microenvironment with spatiotemporal resolution. To satisfy this need, analytical methods based on fluorescence probes offer great opportunities due to the facile, sensitive, and dynamic detection that these molecules could enable in…
Citation impact
- FWCI
- 74.11
- Percentile
- 100%
- References
- 532
Authors
6- JMJunbao Ma
Westlake University
- RSRui Sun
Dalian Institute of Chemical Physics, Chinese Academy of Sciences, University of Chinese Academy of Sciences
- KXKaifu Xia
Westlake University
- QXQiuxuan Xia
Dalian Institute of Chemical Physics, Chinese Academy of Sciences, University of Chinese Academy of Sciences
- YLYu LiuCorresponding
Dalian Institute of Chemical Physics, Chinese Academy of Sciences
Topics & keywords
- Chemistry
- Fluorescence
- Nanotechnology
- Biophysics
- Biological system
- Polarity (international relations)
- Biological fluids
- Cell