KAT8-catalyzed lactylation promotes eEF1A2-mediated protein synthesis and colorectal carcinogenesis
Beijing Institute of Technology · Ministry of Industry and Information Technology · +7 more institutions
Abstract
Aberrant lysine lactylation (Kla) is associated with various diseases which are caused by excessive glycolysis metabolism. However, the regulatory molecules and downstream protein targets of Kla remain largely unclear. Here, we observed a global Kla abundance profile in colorectal cancer (CRC) that negatively correlates with prognosis. Among lactylated proteins detected in CRC, lactylation of eEF1A2K408 resulted in boosted translation elongation and enhanced protein synthesis which contributed to tumorigenesis. By screening eEF1A2 interacting proteins, we identified that KAT8, a lysine acetyltransferase that acted as a pan-Kla writer, was responsible for installing Kla on many protein substrates involving in…
Citation impact
- FWCI
- 43.73
- Percentile
- 100%
- References
- 45
Authors
17- BXBingteng XieCorresponding
Beijing Institute of Technology, Ministry of Industry and Information Technology
- MZMengdi ZhangCorresponding
Chinese Academy of Medical Sciences & Peking Union Medical College
- JLJie LiCorresponding
Peking University, Peking University Third Hospital
- JCJianxin Cui
Chinese People's Liberation Army
- PZPengju Zhang
Chinese Academy of Medical Sciences & Peking Union Medical College
Topics & keywords
- Carcinogenesis
- Lysine
- Protein biosynthesis
- Colorectal cancer
- Translation (biology)
- Glycolysis
- Chemistry
- Biology
- Good health and well-being