Autophagy-driven regulation of cisplatin response in human cancers: Exploring molecular and cell death dynamics

Despite the challenges posed by drug resistance and side effects, chemotherapy remains a pivotal strategy in cancer treatment. A key issue in this context is macroautophagy (commonly known as autophagy), a dysregulated cell death mechanism often observed during chemotherapy. Autophagy plays a cytoprotective role by maintaining cellular homeostasis and recycling organelles, and emerging evidence points to its significant role in promoting cancer progression. Cisplatin, a DNA-intercalating agent known for inducing cell death and cell cycle arrest, often encounters resistance in chemotherapy treatments. Recent studies have shown that autophagy can contribute to cisplatin resistance or insensitivity in tumor cells…

• LA
  Lotte and John Hecht Memorial Foundation
• CC
  Canadian Cardiovascular Society

  Award: 707683
• CC
  Canadian Cancer Society
• TF
  Terry Fox Research Institute
• CI
  Canadian Institutes of Health Research

  Awards: 186331, 180554, 173338, 153081