Boosting cartilage repair with silk fibroin-DNA hydrogel-based cartilage organoid precursor

Osteoarthritis (OA), a common degenerative disease, is characterized by high disability and imposes substantial economic impacts on individuals and society. Current clinical treatments remain inadequate for effectively managing OA. Organoids, miniature 3D tissue structures from directed differentiation of stem or progenitor cells, mimic native organ structures and functions. They are useful for drug testing and serve as active grafts for organ repair. However, organoid construction requires extracellular matrix-like 3D scaffolds for cellular growth. Hydrogel microspheres, with tunable physical and chemical properties, show promise in cartilage tissue engineering by replicating the natural microenvironment.…

• NN
  National Natural Science Foundation of China

  Awards: 82230071, 92249303, 32101084
• NK
  National Key Research and Development Program of China

  Award: 2022YFB3804300