STING licensing of type I dendritic cells potentiates antitumor immunity

Stimulator of interferon genes (STING) is an immune adaptor protein that senses cyclic GMP-AMP in response to self or microbial cytosolic DNA as a danger signal. STING is ubiquitously expressed in diverse cell populations, including cancer cells, with distinct cellular functions, such as activation of type I interferons, autophagy induction, or triggering apoptosis. It is not well understood whether and which subsets of immune cells, stromal cells, or cancer cells are particularly important for STING-mediated antitumor immunity. Here, using a polymeric STING-activating nanoparticle (PolySTING) with a shock-and-lock dual activation mechanism, we show that conventional type 1 dendritic cells (cDC1s) are…

• JH
  Johns Hopkins University
• UO
  University of Texas Southwestern Medical Center
• NN
  National Natural Science Foundation of China

  Award: U20A20375
• NI
  National Institutes of Health

  Awards: U54 CA244719, R01CA216839