Cellular uptake and in vivo distribution of mesenchymal-stem-cell-derived extracellular vesicles are protein corona dependent

Liam‐Or, Revadee; Faruqu, Farid N.; Walters, Adam A.; Han, Shunping; Xu, Lizhou; Wang, Julie; Oberlaender, Jennifer; Sánchez‐Fueyo, Alberto; Lombardi, Giovanna; Dazzi, Francesco; Mailaender, Volker; Al‐Jamal, Khuloud T.

doi:10.1038/s41565-023-01585-y

articleNature NanotechnologyFeb 16, 2024HYBRID OA

Cellular uptake and in vivo distribution of mesenchymal-stem-cell-derived extracellular vesicles are protein corona dependent

RLRevadee Liam‐Or FNFarid N. Faruqu AAAdam A. Walters SHShunping Han LXLizhou Xu

King's College London · University of Malaya · +5 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Extracellular vesicles (EVs) derived from mesenchymal stem cells are promising nanotherapeutics in liver diseases due to their regenerative and immunomodulatory properties. Nevertheless, a concern has been raised regarding the rapid clearance of exogenous EVs by phagocytic cells. Here we explore the impact of protein corona on EVs derived from two culturing conditions in which specific proteins acquired from media were simultaneously adsorbed on the EV surface. Additionally, by incubating EVs with serum, simulating protein corona formation upon systemic delivery, further resolved protein corona-EV complex patterns were investigated. Our findings reveal the potential influences of corona composition on EVs…

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165

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Topics & keywords

Topics

Keywords

In vivo
Mesenchymal stem cell
Cell biology
Vesicle
Hepatic stellate cell
Biophysics
Immune system
Chemistry

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