Insights and implications of sexual dimorphism in osteoporosis
Sichuan University · West China Medical Center of Sichuan University · +6 more institutions
Abstract
Abstract Osteoporosis, a metabolic bone disease characterized by low bone mineral density and deterioration of bone microarchitecture, has led to a high risk of fatal osteoporotic fractures worldwide. Accumulating evidence has revealed that sexual dimorphism is a notable feature of osteoporosis, with sex-specific differences in epidemiology and pathogenesis. Specifically, females are more susceptible than males to osteoporosis, while males are more prone to disability or death from the disease. To date, sex chromosome abnormalities and steroid hormones have been proven to contribute greatly to sexual dimorphism in osteoporosis by regulating the functions of bone cells. Understanding the sex-specific…
Citation impact
- FWCI
- 53.32
- Percentile
- 100%
- References
- 540
Authors
8Topics & keywords
- Sexual dimorphism
- Osteoporosis
- Biology
- Evolutionary biology
- Medicine
- Internal medicine
- Bioinformatics
- Good health and well-being