Genomic data in the All of Us Research Program

Abstract Comprehensively mapping the genetic basis of human disease across diverse individuals is a long-standing goal for the field of human genetics 1–4 . The All of Us Research Program is a longitudinal cohort study aiming to enrol a diverse group of at least one million individuals across the USA to accelerate biomedical research and improve human health 5,6 . Here we describe the programme’s genomics data release of 245,388 clinical-grade genome sequences. This resource is unique in its diversity as 77% of participants are from communities that are historically under-represented in biomedical research and 46% are individuals from under-represented racial and ethnic minorities. All of Us identified more…

• UD
  U.S. Department of Health and Human Services
• NI
  National Institutes of Health

  Awards: OD026553, OT2 OD002748, OT2 OD002750, OT2 OD026551, U24 OD023121, AOD 16037, OT2 OD002751, OT2 OD025277, OT2 OD025315, OT2 OD026557, U2C OD023196, OT2 OD 026552, OT2 OD026553, OT2 OD023206, OT2 OD026554, OT2 OD026556, OT2 OD026550, OT2 OD026548, OT2 OD026555, OT2 OD026549, OT2 OD025337, U24 OD023163, OT2 OD025276, U24 OD023176, HHSN 263201600085U, 263201600085U, OT2 OD023205