articleNatureFeb 19, 2024HYBRID OA

Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

KSKen SuzukiKHKonstantinos HatzikotoulasLSLorraine SouthamHJHenry J. TaylorXYXianyong Yin

University of Manchester · Arthritis UK · +216 more institutions

PubMed
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Abstract

Abstract Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes 1,2 and molecular mechanisms that are often specific to cell type 3,4 . Here, to characterize the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases of T2D. We identify 1,289 independent association signals at genome-wide significance ( P < 5 × 10 −8 ) that map to 611 loci, of which 145 loci are, to our knowledge, previously unreported. We define eight non-overlapping clusters of T2D signals that are characterized by distinct profiles of…

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Topics & keywords

Topics
Keywords
  • Genome-wide association study
  • Type 2 diabetes
  • Biology
  • Genetic association
  • Genetics
  • Epigenomics
  • Disease
  • Genetic architecture
UN Sustainable Development Goals
  • Good health and well-being
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