Gut microbiota‐derived short‐chain fatty acids and depression: deep insight into biological mechanisms and potential applications
Central South University · National Clinical Research · +3 more institutions
Abstract
The gut microbiota is a complex and dynamic ecosystem known as the 'second brain'. Composing the microbiota-gut-brain axis, the gut microbiota and its metabolites regulate the central nervous system through neural, endocrine and immune pathways to ensure the normal functioning of the organism, tuning individuals' health and disease status. Short-chain fatty acids (SCFAs), the main bioactive metabolites of the gut microbiota, are involved in several neuropsychiatric disorders, including depression. SCFAs have essential effects on each component of the microbiota-gut-brain axis in depression. In the present review, the roles of major SCFAs (acetate, propionate and butyrate) in the pathophysiology of depression…
Citation impact
- FWCI
- 19.84
- Percentile
- 100%
- References
- 226
Authors
7- JCJunzhe Cheng
Central South University, National Clinical Research, Second Xiangya Hospital of Central South University
- HHHongkun Hu
Central South University
- YJYumeng Ju
Central South University, National Clinical Research, Second Xiangya Hospital of Central South University, Hunan Institute of Mental Health
- JLJin Liu
Central South University, National Clinical Research, Second Xiangya Hospital of Central South University, Hunan Institute of Mental Health
- MWMi Wang
Central South University, Xiangya Hospital Central South University
Topics & keywords
- Gut flora
- Gut–brain axis
- Biology
- Neuroinflammation
- Butyrate
- Immune system
- Endocrine system
- Neuroscience