Gut dysbiosis induces the development of depression-like behavior through abnormal synapse pruning in microglia-mediated by complement C3

Abstract Background Remodeling eubiosis of the gut microenvironment may contribute to preventing the occurrence and development of depression. Mounting experimental evidence has shown that complement C3 signaling is associated with the pathogenesis of depression, and disruption of the gut microbiota may be an underlying cause of complement system activation. However, the mechanism by which complement C3 participates in gut-brain crosstalk in the pathogenesis of depression remains unknown. Results In the present study, we found that chronic unpredictable mild stress (CUMS)-induced mice exhibited obvious depression-like behavior as well as cognitive impairment, which was associated with significant gut…

• NN
  National Natural Science Foundation of China

  Awards: 82074300, 82174278, 201911, 82074300, 82174278, 2021B1212040007
• SY
  Sun Yat-sen University
• CP
  China Postdoctoral Science Foundation

  Award: 2023M741396
• JU
  Jinan University

  Award: 201911
• BA
  Basic and Applied Basic Research Foundation of Guangdong Province