Emerging role of senescent microglia in brain aging-related neurodegenerative diseases
CHA University · Korea Brain Research Institute · +1 more institution
Abstract
Brain aging is a recognized risk factor for neurodegenerative diseases like Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), but the intricate interplay between brain aging and the pathogenesis of these conditions remains inadequately understood. Cellular senescence is considered to contribute to cellular dysfunction and inflammaging. According to the threshold theory of senescent cell accumulation, the vulnerability to neurodegenerative diseases is associated with the rates of senescent cell generation and clearance within the brain. Given the role of microglia in eliminating senescent cells, the accumulation of senescent microglia may lead to the…
Citation impact
- FWCI
- 25.01
- Percentile
- 100%
- References
- 162
Authors
4Topics & keywords
- Microglia
- Neuroscience
- Amyotrophic lateral sclerosis
- Senescence
- Disease
- Aging brain
- Neurodegeneration
- Medicine