Deep phenotyping of post-infectious myalgic encephalomyelitis/chronic fatigue syndrome

Post-infectious myalgic encephalomyelitis/chronic fatigue syndrome (PI-ME/CFS) is a disabling disorder, yet the clinical phenotype is poorly defined, the pathophysiology is unknown, and no disease-modifying treatments are available. We used rigorous criteria to recruit PI-ME/CFS participants with matched controls to conduct deep phenotyping. Among the many physical and cognitive complaints, one defining feature of PI-ME/CFS was an alteration of effort preference, rather than physical or central fatigue, due to dysfunction of integrative brain regions potentially associated with central catechol pathway dysregulation, with consequences on autonomic functioning and physical conditioning. Immune profiling…

• NI
  National Institutes of Health

  Award: ES103362
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  National Institute on Aging
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  National Heart, Lung, and Blood Institute

  Award: HL006210; HL006212; HL005199
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  National Institute of Mental Health

  Award: MH002922
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  National Institute on Drug Abuse
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  National Cancer Institute
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  National Institute of Nursing Research
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  National Institute of Allergy and Infectious Diseases
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  National Institute of Diabetes and Digestive and Kidney Diseases

  Award: DK071014
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  National Institute of Neurological Disorders and Stroke

  Awards: ZIA NS003157, NS3157
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  National Institute of Environmental Health Sciences

  Award: ES103362
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  National Institute of Arthritis and Musculoskeletal and Skin Diseases
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  National Institute of Dental and Craniofacial Research
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  NIH Clinical Center
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  National Center for Complementary and Integrative Health
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  Common Fund