Annexins—a family of proteins with distinctive tastes for cell signaling and membrane dynamics
University of Münster · Institute of Molecular Biology · +8 more institutions
Abstract
Abstract Annexins are cytosolic proteins with conserved three-dimensional structures that bind acidic phospholipids in cellular membranes at elevated Ca 2+ levels. Through this they act as Ca 2+ -regulated membrane binding modules that organize membrane lipids, facilitating cellular membrane transport but also displaying extracellular activities. Recent discoveries highlight annexins as sensors and regulators of cellular and organismal stress, controlling inflammatory reactions in mammals, environmental stress in plants, and cellular responses to plasma membrane rupture. Here, we describe the role of annexins as Ca 2+ -regulated membrane binding modules that sense and respond to cellular stress and share our…
Citation impact
- FWCI
- 24.96
- Percentile
- 100%
- References
- 154
Authors
7- VGVolker GerkeCorresponding
University of Münster, Institute of Molecular Biology
- FNFelicity N. E. Gavins
Centre for Inflammation Research, Brunel University of London
- MJMichael J. Geisow
Biotec (United Kingdom)
- TGThomas Grewal
The University of Sydney
- JKJyoti K. Jaiswal
Children's National, George Washington University
Topics & keywords
- Cell biology
- Signal transduction
- Dynamics (music)
- Signaling proteins
- Membrane protein
- Cell
- Biology
- Chemistry
- Life in Land