articleNature NeuroscienceFeb 22, 2024HYBRID OA

Mapping dysfunctional circuits in the frontal cortex using deep brain stimulation

BHBarbara HollunderJLJill L. OstremIAIlkem Aysu SahinNRNanditha RajamaniSOSimón Oxenford

Humboldt-Universität zu Berlin · Einstein Center for Neurosciences Berlin · +26 more institutions

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Abstract

Frontal circuits play a critical role in motor, cognitive and affective processing, and their dysfunction may result in a variety of brain disorders. However, exactly which frontal domains mediate which (dys)functions remains largely elusive. We studied 534 deep brain stimulation electrodes implanted to treat four different brain disorders. By analyzing which connections were modulated for optimal therapeutic response across these disorders, we segregated the frontal cortex into circuits that had become dysfunctional in each of them. Dysfunctional circuits were topographically arranged from occipital to frontal, ranging from interconnections with sensorimotor cortices in dystonia, the primary motor cortex in…

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Topics & keywords

Topics
Keywords
  • Neuroscience
  • Deep brain stimulation
  • Psychology
  • Connectomics
  • Dysfunctional family
  • Brain stimulation
  • Prefrontal cortex
  • Anterior cingulate cortex
UN Sustainable Development Goals
  • Good health and well-being
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