Ultrasmall metal alloy nanozymes mimicking neutrophil enzymatic cascades for tumor catalytic therapy

Meng, Xiangqin; Fan, Huizhen; Chen, Lei; He, Jiuyang; Hong, Chaoyi; Xie, Jiaying; Hou, Yinyin; Wang, Kaidi; Gao, Xingfa; Gao, Lizeng; Yan, Xiyun; Fan, Kelong

doi:10.1038/s41467-024-45668-3

articleNature CommunicationsFeb 22, 2024GOLD OA

Ultrasmall metal alloy nanozymes mimicking neutrophil enzymatic cascades for tumor catalytic therapy

XMXiangqin Meng HFHuizhen Fan LCLei Chen JHJiuyang He CHChaoyi Hong

Institute of Biophysics · Yangzhou University · +6 more institutions

PubMed

Indexed incrossrefdoajpubmed

Abstract

Abstract Developing strategies that emulate the killing mechanism of neutrophils, which involves the enzymatic cascade of superoxide dismutase (SOD) and myeloperoxidase (MPO), shows potential as a viable approach for cancer therapy. Nonetheless, utilizing natural enzymes as therapeutics is hindered by various challenges. While nanozymes have emerged for cancer treatment, developing SOD-MPO cascade in one nanozyme remains a challenge. Here, we develop nanozymes possessing both SOD- and MPO-like activities through alloying Au and Pd, which exhibits the highest cascade activity when the ratio of Au and Pd is 1:3, attributing to the high d-band center and adsorption energy for superoxide anions, as determined…

Citation impact

172

total citations

FWCI: 18.70
Percentile: 100%
References: 61

Citations per year

Authors

12

Topics & keywords

Topics

Keywords

Myeloperoxidase
Chemistry
Enzyme
Superoxide dismutase
Catalysis
Cancer therapy
Superoxide
Cascade

UN Sustainable Development Goals

Good health and well-being

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