Ultrasound-activated piezo-hot carriers trigger tandem catalysis coordinating cuproptosis-like bacterial death against implant infections
Fujian Normal University · Sichuan University · +5 more institutions
Abstract
Abstract Implant-associated infections due to the formation of bacterial biofilms pose a serious threat in medical healthcare, which needs effective therapeutic methods. Here, we propose a multifunctional nanoreactor by spatiotemporal ultrasound-driven tandem catalysis to amplify the efficacy of sonodynamic and chemodynamic therapy. By combining piezoelectric barium titanate with polydopamine and copper, the ultrasound-activated piezo-hot carriers transfer easily to copper by polydopamine. It boosts reactive oxygen species production by piezoelectrics, and facilitates the interconversion between Cu2 + and Cu + to promote hydroxyl radical generation via Cu + -catalyzed chemodynamic reactions. Finally, the…
Citation impact
- FWCI
- 27.89
- Percentile
- 100%
- References
- 47
Authors
14Topics & keywords
- Nanoreactor
- Sonodynamic therapy
- Reactive oxygen species
- Chemistry
- Catalysis
- In vivo
- Biophysics
- Biochemistry