Recent Advances in Intranasal Administration for Brain-Targeting Delivery: A Comprehensive Review of Lipid-Based Nanoparticles and Stimuli-Responsive Gel Formulations

Addressing disorders related to the central nervous system (CNS) remains a complex challenge because of the presence of the blood-brain barrier (BBB), which restricts the entry of external substances into the brain tissue. Consequently, finding ways to overcome the limited therapeutic effect imposed by the BBB has become a central goal in advancing delivery systems targeted to the brain. In this context, the intranasal route has emerged as a promising solution for delivering treatments directly from the nose to the brain through the olfactory and trigeminal nerve pathways and thus, bypassing the BBB. The use of lipid-based nanoparticles, including nano/microemulsions, liposomes, solid lipid nanoparticles, and…

• NR
  National Research Foundation
• NR
  National Research Foundation of Korea

  Awards: 2022R1C1C2002949, 2021R1A2C2008519, 2022R1A5A6000760
• MO
  Ministry of Science and ICT, South Korea

  Awards: 2021R1A2C2008519, 2022R1A5A6000760, 2022R1C1C2002949