Assessment of Advanced Diagnostic Bronchoscopy Outcomes for Peripheral Lung Lesions: A Delphi Consensus Definition of Diagnostic Yield and Recommendations for Patient-centered Study Designs. An Official American Thoracic Society/American College of Chest Physicians Research Statement

Abstract Background Advanced diagnostic bronchoscopy targeting the lung periphery has developed at an accelerated pace over the last two decades, whereas evidence to support introduction of innovative technologies has been variable and deficient. A major gap relates to variable reporting of diagnostic yield, in addition to limited comparative studies. Objectives To develop a research framework to standardize the evaluation of advanced diagnostic bronchoscopy techniques for peripheral lung lesions. Specifically, we aimed for consensus on a robust definition of diagnostic yield, and we propose potential study designs at various stages of technology development. Methods Panel members were selected for their…

• UD
  U.S. Department of Veterans Affairs
• AT
  American Thoracic Society
• A
  Amgen
• BS
  Bristol-Myers Squibb
• EL
  Eli Lilly and Company
• A
  AstraZeneca
• S
  Sanofi
• UO
  University of Rochester
• BS
  Boston Scientific Corporation
• IS
  Intuitive Surgical
• NC
  National Comprehensive Cancer Network
• E
  EQRx
• NI
  National Institutes of Health
• G
  Genentech
• MC
  Medical Center, University of Rochester
• MR
  Medical Research Council

  Award: MR/T02481X/1