articleSchizophrenia BulletinFeb 24, 2024BRONZE OA

Network Localization of State and Trait of Auditory Verbal Hallucinations in Schizophrenia

Anhui Agricultural University · Anhui Medical University · +2 more institutions

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Abstract

BACKGROUND AND HYPOTHESIS: Neuroimaging studies investigating the neural substrates of auditory verbal hallucinations (AVH) in schizophrenia have yielded mixed results, which may be reconciled by network localization. We sought to examine whether AVH-state and AVH-trait brain alterations in schizophrenia localize to common or distinct networks. STUDY DESIGN: We initially identified AVH-state and AVH-trait brain alterations in schizophrenia reported in 48 previous studies. By integrating these affected brain locations with large-scale discovery and validation resting-state functional magnetic resonance imaging datasets, we then leveraged novel functional connectivity network mapping to construct AVH-state and…

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