Resistant starch intake facilitates weight loss in humans by reshaping the gut microbiota

Li, Huating; Zhang, Lei; Li, Jun; Wu, Qian; Qian, Lingling; He, Junsheng; Ni, Yueqiong; Kovatcheva‐Datchary, Petia; Yuan, Rui; Liu, Shuangbo; Shen, Li; Zhang, Mingliang; Sheng, Bin; Li, Ping; Kang, Kang; Wu, Liang; Fang, Qichen; Long, Xiaoxue; Wang, Xiaolin; Li, Yanli; Ye, Yaorui; Ye, Jianping; Bao, Yuqian; Zhao, Yueliang; Xu, Guowang; Liu, Xinyu; Panagiotou, Gianni; Xu, Aimin; Jia, Weiping

doi:10.1038/s42255-024-00988-y

articleNature MetabolismFeb 26, 2024HYBRID OA

Resistant starch intake facilitates weight loss in humans by reshaping the gut microbiota

HLHuating Li LZLei Zhang JLJun Li QWQian Wu LQLingling Qian

Shanghai Jiao Tong University · Shanghai Sixth People's Hospital · +13 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Emerging evidence suggests that modulation of gut microbiota by dietary fibre may offer solutions for metabolic disorders. In a randomized placebo-controlled crossover design trial (ChiCTR-TTRCC-13003333) in 37 participants with overweight or obesity, we test whether resistant starch (RS) as a dietary supplement influences obesity-related outcomes. Here, we show that RS supplementation for 8 weeks can help to achieve weight loss (mean -2.8 kg) and improve insulin resistance in individuals with excess body weight. The benefits of RS are associated with changes in gut microbiota composition. Supplementation with Bifidobacterium adolescentis, a species that is markedly associated with the alleviation of obesity…

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Topics & keywords

Topics

Keywords

Resistant starch
Gut flora
Obesity
Weight loss
Overweight
Insulin resistance
Crossover study
Endocrinology

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