Drinkable in situ-forming tough hydrogels for gastrointestinal therapeutics
Massachusetts Institute of Technology · Yale University · +9 more institutions
Abstract
Pills are a cornerstone of medicine but can be challenging to swallow. While liquid formulations are easier to ingest, they lack the capacity to localize therapeutics with excipients nor act as controlled release devices. Here we describe drug formulations based on liquid in situ-forming tough (LIFT) hydrogels that bridge the advantages of solid and liquid dosage forms. LIFT hydrogels form directly in the stomach through sequential ingestion of a crosslinker solution of calcium and dithiol crosslinkers, followed by a drug-containing polymer solution of alginate and four-arm poly(ethylene glycol)-maleimide. We show that LIFT hydrogels robustly form in the stomachs of live rats and pigs, and are mechanically…
Citation impact
- FWCI
- 16.63
- Percentile
- 100%
- References
- 49
Authors
22- GWGary W. LiuCorresponding
Massachusetts Institute of Technology
- MJMatthew J. Pickett
Yale University, Massachusetts Institute of Technology
- JKJohannes Kuosmanen
Massachusetts Institute of Technology
- KIKeiko Ishida
Brigham and Women's Hospital, Harvard University, Fractyl (United States), Massachusetts Institute of Technology
- WAWiam Abdalla Mohammed Madani
Cornell University, Massachusetts Institute of Technology
Topics & keywords
- Self-healing hydrogels
- In situ
- Materials science
- Nanotechnology
- Biomedical engineering
- Medicine
- Chemistry
- Polymer chemistry