reviewCellsFeb 28, 2024GOLD OA

Role of Inflammatory Mechanisms in Major Depressive Disorder: From Etiology to Potential Pharmacological Targets

BRBruna R. KoubaLALaura A. BorbaPBPedro Borges de SouzaJGJoana Gil‐MohapelALAna Lúcia S. Rodrigues

Universidade Federal de Santa Catarina · University of British Columbia · +1 more institution

PubMed
Indexed incrossrefdoajpubmed

Abstract

The involvement of central and peripheral inflammation in the pathogenesis and prognosis of major depressive disorder (MDD) has been demonstrated. The increase of pro-inflammatory cytokines (interleukin (IL)-1β, IL-6, IL-18, and TNF-α) in individuals with depression may elicit neuroinflammatory processes and peripheral inflammation, mechanisms that, in turn, can contribute to gut microbiota dysbiosis. Together, neuroinflammation and gut dysbiosis induce alterations in tryptophan metabolism, culminating in decreased serotonin synthesis, impairments in neuroplasticity-related mechanisms, and glutamate-mediated excitotoxicity. This review aims to highlight the inflammatory mechanisms (neuroinflammation,…

Citation impact

177
total citations
FWCI
25.26
Percentile
100%
References
339
Citations per year

Authors

5

Topics & keywords

Topics
Keywords
  • Neuroinflammation
  • Inflammation
  • Dysbiosis
  • Medicine
  • Excitotoxicity
  • Gut–brain axis
  • Gut flora
  • Major depressive disorder
UN Sustainable Development Goals
  • Good health and well-being
No related works found for this paper.

Funding