Data leakage inflates prediction performance in connectome-based machine learning models

Predictive modeling is a central technique in neuroimaging to identify brain-behavior relationships and test their generalizability to unseen data. However, data leakage undermines the validity of predictive models by breaching the separation between training and test data. Leakage is always an incorrect practice but still pervasive in machine learning. Understanding its effects on neuroimaging predictive models can inform how leakage affects existing literature. Here, we investigate the effects of five forms of leakage-involving feature selection, covariate correction, and dependence between subjects-on functional and structural connectome-based machine learning models across four datasets and three…

• NS
  National Science Foundation

  Award: DGE2139841
• NI
  National Institute of Mental Health

  Awards: R01MH121095, R00MH130894