A DNA tetrahedron-based ferroptosis-suppressing nanoparticle: superior delivery of curcumin and alleviation of diabetic osteoporosis

Diabetic osteoporosis (DOP) is a significant complication that poses continuous threat to the bone health of patients with diabetes; however, currently, there are no effective treatment strategies. In patients with diabetes, the increased levels of ferroptosis affect the osteogenic commitment and differentiation of bone mesenchymal stem cells (BMSCs), leading to significant skeletal changes. To address this issue, we aimed to target ferroptosis and propose a novel therapeutic approach for the treatment of DOP. We synthesized ferroptosis-suppressing nanoparticles, which could deliver curcumin, a natural compound, to the bone marrow using tetrahedral framework nucleic acid (tFNA). This delivery system…

• NN
  National Natural Science Foundation of China

  Awards: 82370929, 202102, 2019YFA0110600, 82370932, 81970917, 81970916, 81800947, 82101077
• SU
  Sichuan University
• SP
  Sichuan Province Youth Science and Technology Innovation Team

  Award: 2022JDTD0021
• NN
  National Natural Science Foundation of China-Yunnan Joint Fund

  Award: 82370929，81970916
• WC
  West China Hospital, Sichuan University

  Awards: RD-03-202102, RD03202302