articleAdvanced ScienceMar 2, 2024GOLD OA

Elesclomol Loaded Copper Oxide Nanoplatform Triggers Cuproptosis to Enhance Antitumor Immunotherapy

XLXufeng LuXCXiaodong ChenCLChengyin LinYYYongdong YiSZShengsheng Zhao

Wenzhou Medical University · Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University · +1 more institution

PubMed
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Abstract

Abstract The induction of cuproptosis, a recently identified form of copper‐dependent immunogenic cell death, is a promising approach for antitumor therapy. However, sufficient accumulation of intracellular copper ions (Cu 2+ ) in tumor cells is essential for inducing cuproptosis. Herein, an intelligent cuproptosis‐inducing nanosystem is constructed by encapsulating copper oxide (CuO) nanoparticles with the copper ionophore elesclomol (ES). After uptake by tumor cells, ES@CuO is degraded to release Cu 2+ and ES to synergistically trigger cuproptosis, thereby significantly inhibiting the tumor growth of murine B16 melanoma cells. Moreover, ES@CuO further promoted cuproptosis‐mediated immune responses and…

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135
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22.59
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100%
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Authors

18

Topics & keywords

Topics
Keywords
  • Immunotherapy
  • Melanoma
  • Tumor microenvironment
  • Cancer research
  • Immune system
  • Immunogenic cell death
  • Intracellular
  • Programmed cell death
UN Sustainable Development Goals
  • Good health and well-being
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