ROS signaling in innate immunity via oxidative protein modifications
Palacký University Olomouc · National Research Tomsk State University · +4 more institutions
Abstract
The innate immune response represents the first-line of defense against invading pathogens. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) have been implicated in various aspects of innate immune function, which involves respiratory bursts and inflammasome activation. These reactive species widely distributed within the cellular environment are short-lived intermediates that play a vital role in cellular signaling and proliferation and are likely to depend on their subcellular site of formation. NADPH oxidase complex of phagocytes is known to generate superoxide anion radical (O 2 •− ) that functions as a precursor for antimicrobial hydrogen peroxide (H 2 O 2 ) production, and H 2 O 2 is…
Citation impact
- FWCI
- 25.30
- Percentile
- 100%
- References
- 116
Authors
4- RRRenuka Ramalingam Manoharan
Palacký University Olomouc
- APAnkush PrasadCorresponding
Palacký University Olomouc
- PPPavel Pospı́šil
Palacký University Olomouc
- JKJulia KzhyshkowskaCorresponding
National Research Tomsk State University, Siberian State Medical University, Heidelberg University, German Red Cross, University Hospital Heidelberg
Topics & keywords
- Innate immune system
- Cell biology
- NADPH oxidase
- Hypochlorous acid
- Reactive oxygen species
- Respiratory burst
- Myeloperoxidase
- Superoxide
- Life in Land
Funding
- TSTomsk State UniversityAward: Priority-2030
- MOMinistry of Science and Higher Education of the Russian FederationAwards: 075-15-2021-1073, 075-15-
- EREuropean Regional Development FundAwards: 02.1.01/0.0/0.0, CZ.02.1.01/0.0/0.0/16_019/0000827, CZ.02, CZ.02.1.01, CZ.02.1.01/0.0/0.0, CZ.02.1.01/0.0/0.0/, 02.1.01/0.0/0.0/16_019/0000827, /16_019, /0000827