The Hippo signaling pathway in development and regeneration

The Hippo signaling pathway is a central growth control mechanism in multicellular organisms. By integrating diverse mechanical, biochemical, and stress cues, the Hippo pathway orchestrates proliferation, survival, differentiation, and mechanics of cells, which in turn regulate organ development, homeostasis, and regeneration. A deep understanding of the regulation and function of the Hippo pathway therefore holds great promise for developing novel therapeutics in regenerative medicine. Here, we provide updates on the molecular organization of the mammalian Hippo signaling network, review the regulatory signals and functional outputs of the pathway, and discuss the roles of Hippo signaling in development and…

• SM
  Shanghai Municipal Health Commission

  Award: 2022XD049
• NN
  National Natural Science Foundation of China

  Award: 32370770
• MO
  Ministry of Science and Technology of the People's Republic of China
• SA
  Science and Technology Commission of Shanghai Municipality

  Award: 21S11905000
• NK
  National Key Research and Development Program of China

  Awards: 2018YFA0800304, 2020YFA0803202