Exosome circATP8A1 induces macrophage M2 polarization by regulating the miR-1-3p/STAT6 axis to promote gastric cancer progression

Circular RNAs (circRNAs) play important roles in gastric cancer progression but the regulatory role of circRNAs in controlling macrophage function remains elusive. Exosomes serve as cargo for circRNAs and play a crucial role as mediators in facilitating communication between cancer cells and the tumor microenvironment. In this study, we found that circATP8A1, a previously unreported circular RNA, is highly expressed in both gastric cancer tissues and exosomes derived from plasma. Increased circATP8A1 was associated with advanced TNM stage and worse prognosis in patients with gastric cancer. We showed that the circATP8A1 knockdown significantly inhibited gastric cancer proliferation and invasion in vitro and in…

• NN
  National Natural Science Foundation of China

  Awards: 82102716, 82220108013, 82200569, 82073148, U20A20379, 82220108013, 82073148, 82200569 and 82102716, U20A20379, 2021B1212040006
• CP
  China Postdoctoral Science Foundation

  Awards: 2022M713588 and 2023M744016, 2022M713588
• SP
  Sanming Project of Medicine in Shenzhen

  Awards: 2021B1212040006, SZSM201911010
• BA
  Basic and Applied Basic Research Foundation of Guangdong Province

  Awards: 2023A1515010473, 2021A1515111011
• HE
  HORIZON EUROPE Excellent Science