articleExpert Opinion on Drug DiscoveryMar 8, 2024Closed access

Molecular hybridization: a powerful tool for multitarget drug discovery

PDPedro de Sena Murteira PinheiroLSLucas Silva FrancoTLTadeu L. MontagnoliCACarlos Alberto Manssour Fraga

Universidade Federal do Rio de Janeiro

PubMed
Indexed incrossrefpubmed

Abstract

INTRODUCTION: The current drug discovery paradigm of 'one drug, multiple targets' has gained attention from both the academic medicinal chemistry community and the pharmaceutical industry. This is in response to the urgent need for effective agents to treat multifactorial chronic diseases. The molecular hybridization strategy is a useful tool that has been widely explored, particularly in the last two decades, for the design of multi-target drugs. AREAS COVERED: This review examines the current state of molecular hybridization in guiding the discovery of multitarget small molecules. The article discusses the design strategies and target selection for a multitarget polypharmacology approach to treat various…

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147
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31.06
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100%
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143
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Authors

4

Topics & keywords

Topics
Keywords
  • Drug discovery
  • Pharmacophore
  • Computational biology
  • Disease
  • Biology
  • Drug
  • Bioinformatics
  • Neuroscience
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