Molecular Crowding: The History and Development of a Scientific Paradigm

Alfano, Caterina; Fichou, Yann; Huber, Klaus; Weiß, Matthias; Spruijt, Evan; Ebbinghaus, Simon; Luca, Giuseppe De; Morando, María Agnese; Vetri, Valeria; Temussi, Piero Andrea; Pastore, Annalisa

doi:10.1021/acs.chemrev.3c00615

reviewChemical ReviewsMar 11, 2024HYBRID OA

Molecular Crowding: The History and Development of a Scientific Paradigm

CACaterina Alfano YFYann Fichou KHKlaus Huber MWMatthias Weiß ESEvan Spruijt

Ri.MED · Centre National de la Recherche Scientifique · +11 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

It is now generally accepted that macromolecules do not act in isolation but "live" in a crowded environment, that is, an environment populated by numerous different molecules. The field of molecular crowding has its origins in the far 80s but became accepted only by the end of the 90s. In the present issue, we discuss various aspects that are influenced by crowding and need to consider its effects. This Review is meant as an introduction to the theme and an analysis of the evolution of the crowding concept through time from colloidal and polymer physics to a more biological perspective. We introduce themes that will be more thoroughly treated in other Reviews of the present issue. In our intentions, each…

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156

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FWCI: 32.80
Percentile: 100%
References: 392

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Topics & keywords

Topics

Keywords

Crowding
Macromolecular crowding
Theme (computing)
Perspective (graphical)
Chemistry
Nanotechnology
Data science
Isolation (microbiology)

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